All About Our Chill Out Formulation – Spore Life Sciences

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All About Our Chill Out Formulation

What Is It?
This adaptogenic blend contains a plethora of antioxidants, vitamins, and minerals for calming, anti-stress blend that offers exactly what you need to slip into that sweet relaxation at the end of the day.
 
What’s In It?
This formula combines the power of the Reishi mushroom with natural herbs like chamomile, lemon balm, and valerian root.
  • Reishi - to enhance immune function and flood the body and mind with tranquility.
  • Chamomile - used as a mild sedative to calm nerves
  • Lemon Balm - can help reduce anxiety
  • Passionflower - helps calm the mind and support sleep cycle
  • Valerian Root - to help with sleep disorders and migraines 

What Does It Do?
Chill Out offers a dense well rounded nutritional profile that allows customers to enjoy this blend in the evening and flood your body with tranquility so you’re ready to enjoy deep, restorative sleep every night.
 
How Does It Work?
The Chill Out formula provides an intelligent array of fungal molecules demonstrated in the scientific literature to offer wellness properties.

Reishi mushrooms, for example, called “the mushroom of immortality” [1], have been studied for their immune-enhancing, anti-inflammatory, antioxidant, anti-tumor, and antimicrobial properties. [2] Ganoderma lucidum – the species relevant to this formula – is reported to have over 400 bioactive compounds mostly comprised of polysaccharides and triterpenoids. The immune-enhancing properties of reishi polysaccharides work by increasing the amounts of key immune cells such as natural killer, B-lymphocyte, T-lymphocyte white blood cells, dendritic cells, phagocytes that protect our bodies from foreign particles and may also be examples of white blood cells. A more robust immune system, in turn, is vital in cancer treatment, and reishi polysaccharides stimulate cancer resistance through their immune-enhancing capabilities, by inducing apoptosis (cell death) of cancerous cells, and through their anti-cancer preventing activity. [3,4] Reishi triterpenes offer anti-cancer properties as well, through their toxicity to cancer cells, anti-metastatic effects, and induction of apoptosis. [3-5] Reishi polysaccharides and triterpenes have shown antioxidant and antimicrobial properties, with the terpenes presenting higher antioxidative capacities. The mushroom’s polysaccharides have also demonstrated anti-aging properties through their ability to protect fibroblasts (cells that provides structural framework in mammalian tissue and aids wound healing) from harmful ultraviolet B (UVB) radiation. [6] The UVB treated cells revealed increased signs of aging and reactive oxygen species and decreased cell viability, but when cells were treated with UVB and reishi polysaccharides, the UVB reactive oxygen species were eliminated. Reishi mushrooms also have been used for their sedative, calming properties. In one study, a reishi extract showed similar anti-anxiety properties as the pharmaceutical drug diazepam. [7] Reishi powder also diminished fatigue, anxiety, and depression, and provided a better quality of life in 48 breast cancer survivors. [8]

The elegance of chamomile cannot be understated. Chamomile contains the terpene alcohol called alpha-bisabolol that imparts significant anti-cancer properties. [9] In addition, chamomile offers well-known anxiolytic, calming properties. Sedative properties have been linked to the flavonoid apigenin. [10] Pre-clinical studies have demonstrated anti-convulsant properties and a depression of the central nervous system. [11] Chamomile tea exhibited a sedative activity similar to benzodiazepines, a class of drugs used in treating anxiety and depression. [12] In a clinical trial, chamomile also showed anxiolytic activity in patients with general anxiety disorder. [13]

The herb Lemon Balm offers another option for stress relief. [14] Records of the use of lemon balm have existed for at least a millennium. A drink containing 300 mg of lemon balm conferred anxiolytic properties as well as providing a better working memory at test durations of 1- and 3-hours after ingestion, demonstrating sustained effects like benzodiazepines. Pre-clinical studies have shown that a lemon balm extract provides similar antidepressant and anxiolytic activity as diazepam, a common drug used to treat anxiety. [15] A double-blind clinical trial involving 24 participants evaluated 3 doses (600, 1200, 1800 mg) of a product containing lemon balm and valerian. [16] The 600 mg dose led to decreased anxiety as demonstrated by the Defined Intensity Stressor Simulation, a series of tasks meant to invoke anxiety.

The Passionflower plant offers a tempting fruit and another source of natural medicine. Passionflower’s anxiolytic properties have been known through folklore and through clinical trials. [17] The clinical trial considered 36 patients diagnosed with general anxiety disorder. Eighteen of the patients received 45 drops of passionflower extract per day while the others received oxazepam, a benzodiazepine used to treat anxiety. There were no significant differences between the effects of the natural substance and pharmaceutical drug, highlighting the power of nature. Another study considered the sleep habits of 41 participants who either ingested passionflower or a placebo tea. [18] The participants who ingested passionflower reported better ratings of sleep quality compared to those who received the placebo. A meta-analysis of nine clinical trials found similar results. [19]

Valerian Root is a common ingredient in many natural sleep aids. A meta-analysis of 60 studies covering a whopping 6,894 participants sought to provide solid conclusions as to whether valerian root improved sleep quality and reduced anxiety. [20] While the studies used extracts that varied in their constituents due to the extraction methods employed, the study authors conclude that “This study demonstrated that valerian could be a safe and useful herb alone and also in combination in treating sleep problems, anxiety, and associated comorbidities.” Valerian root combined with hops presents another option as a sleep remedy. [21] When compared to diphenhydramine (aka Benadryl®), the valerian-hops mixture provided a similar, mildly hypnotic effect to the drug. Study participants reported an increased quality of life at the end of the 28-day treatment compared to the placebo group. Discontinuation of the valerian-hops treatment did not cause insomnia.


These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


References
[1] Stamets P. (2000). Growing Gourmet and Medicinal Mushrooms. Berkeley, CA: Ten Speed Press.
[2] Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009;10(8):717-742.
[3] Cör D, Knez Ž, Knez Hrnčič M. Antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides: A review. Molecules. 2018;23(3):649.
[4] Paterson R.R.M. Ganoderma—A therapeutic fungal biofactory. Phytochemistry. 2006;68:1985–2001.
[5] Sohretoglu D, Huang S. Ganoderma lucidum polysaccharides as an anti-cancer agent. Anticancer Agents Med Chem. 2018;18(5):667-674.
[6] Zeng Q, Zhou F, Lei L, et al. Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging. Mol Med Rep. 2017;15(1):111-116.
[7] Ali N, Muhammad A, & Akbar S.A. Anxiolytic-like activity of ethanol extract of Ganoderma lucidum (Reishi) in mice. International Journal of Medical Research and Health Sciences. 2016;5:57-60.
[8] Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
[9] Cavalieri E, Mariotto S, Fabrizi C, et al. alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004;315(3):589-594.
[10] Avallone R, Zanoli P, Corsi L, Cannazza G and Baraldi M. Benzodiazepine compounds and GABA in flower heads of Matricaria chamomilla. Phytother Res. 1996;10:177-179.
[11] Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Rep. 2010;3(6):895-901.
[12] Shinomiya K, Inoue T, Utsu Y, et al. Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biol Pharm Bull. 2005;28(5):808-810.
[13] Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ and Shults J: A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (Chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009;29:378-382.
[14] Scholey A, Gibbs A, Neale C, et al. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014;6(11):4805-4821.
[15] Taiwo AE, Leite FB, Lucena GM, et al. Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: Influence of administration and gender. Indian J Pharmacol. 2012;44(2):189-192.
[16] Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006;20(2):96-102.
[17] Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001;26(5):363-367.
[18] Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011;25(8):1153-1159.
[19] Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna-Żydecka K. Passiflora incarnata in neuropsychiatric disorders-A systematic review. Nutrients. 2020;12(12):3894.
[20] Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders-A systematic review and meta-analysis. J Evid Based Integr Med. 2020;25:2515690X20967323.
[21] Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005;28(11):1465-1471.

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