The Magic Behind Mike's Mushroom Mix
Powerful functional mushroom blend to keep your body balanced and optimized to perform all day, every day.
What’s In It?
Ten of the most renowned functional mushrooms combined into an all-around daily supplement.
- Agarikon - for anti-inflammatory, antiviral abilities
- Antrodia - to support live tonic
- Chaga - to fight harmful bacteria and viruses
- Cordyceps - natural energy booster
- King Trumpets - to lower cholesterol, help manage diabetes
- Lion’s Mane - for cognition function and memory support
- Maitake - for metabolism support and immune-boosting power.
- Reishi - to enhance immune function and flood the body and mind with tranquility
- Shiitake - to support heart health and skin health
- Turkey tail - for its immune boosting, anti-cancer, and gut health properties
What Does It Do?
Mike’s Mushroom Mix Anti-inflammatory, anti-viral, and immunity booster. Keeps harmful pathogens in check and your body in an optimal state of balance. With a rich profile of phytochemicals such as polysaccharides, triterpenoids, amino acids, and polyphenols, as well as additions of vitamins B, B-12, C, and D and minerals will support your overall health and keep your body’s defense operating at its full capacity. It also helps with metabolism support, anti-aging, and longevity, and strengthening liver function and gut health.
How Does It Work?
The Mike’s Mushroom Mix formula provides an intelligent array of fungal molecules demonstrated in the scientific literature to offer wellness properties.
As with many mushrooms, Agarikon mushrooms offer strong immune-enhancing properties, including activity against viruses including those in the pox family, herpes simplex virus-1 and 2, influenza A and B, bird influenza (H5N1) and tuberculosis. [1-3] Agarikon also offers antimicrobial properties, showing efficacy against some Bacillus, Staphylococcus, Klebsiella, Aspergillus, and Enterobacter species. [4,5] Chlorinated coumarins within Agarikon have provided treatment of pulmonary diseases such as tuberculosis and pneumonia.  Triterpenoids in Agarikon can inhibit nitric oxide production which is involved in inflammatory diseases including asthma.
The fungus Antrodia cinnamomea, or AC mushroom provides immune-enhancing properties like many of the mushrooms selected for use in Spore products. [6-8] The triterpene methyl antcinate K isolated from A. cinnamomea promotes dendritic cells which are vital leukocytes or white blood cells.  Additionally, high-molecular weight polysaccharides from A. cinnamomea have demonstrated adjuvant effects on dendritic cells and in immunotherapy vaccines for cancer.  The polysaccharide galactomannan provides an example of an immunostimulatory compound extracted from Antrodia that enhances resistances against bacterial attacks in the early stages of an infection but also lessens the risk of severe infection by lessening the production of pro-inflammatory cytokines. 
Chaga mushrooms offer anticancer, immune-enhancing, antioxidant, anti-hyperglycemic, and anti-mutagenic (gene-protecting) properties.  Chaga contains compounds such as 3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol (a triterpene), and lanosterol and each of these molecules showed effectiveness against multiple cancer cell lines with low toxicity to normal cells.  Polysaccharides extracted from chaga have reduced tumor size.  Chaga mushrooms also provide immune support, antimutagenic, antimicrobial, and antioxidant activity, and anti-hyperglycemic properties.  For example, chaga mushroom dosing led to decreased DNA damage and an improvement in deformed structures in zebrafish exposed to UVB radiation.  Chaga antioxidant capability prevented the formation of reactive oxygen species helping lessen oxidative stress induced by UV treatment and reduced the amount of pro-inflammatory cytokines brought about by the radiation.  Like reishi mushrooms, chaga aids as an antihyperglycemic agent due to its antioxidative properties and its ability to provide protection against cellular damage.  Chaga mushrooms also provide protection against liver injury by eliminating free radicals, inhibiting the leakage of key enzymes from the induced damage, and decreasing malondialdehyde formation. 
Traditional uses of cordyceps mushrooms include promotion of health, longevity, and athletic power and endurance.  In 1993, Chinese runners who had ingested cordyceps achieved records in several running events, thrusting these mushrooms on the world stage as potential energy enhancers. Thus, cordyceps is used in Spore products to provide a burst of energy. One study demonstrated that, with or without exercising, cordyceps improved exercise endurance by activating skeletal muscle metabolic regulators and increasing antioxidants.  A double-blind, placebo-controlled trial also demonstrated these findings in older adults (ages 50-75 years) who ingested 333 mg of dried mushrooms.  Aerobic performance improved and the ingestion of the mushrooms pointed to resistance to fatigue.
Polysaccharides in king trumpet mushrooms provide powerful antioxidants that help scavenge free radicals and promote key antioxidant enzymes like superoxide dismutase that help reduce oxidative stress.  These polysaccharides also provide anti-tumor effects through immune system modulation. Two such polysaccharides called PEP-1 and PEP-2 demonstrated the ability to provoke apoptosis.  Like other mushrooms that exhibit anti-cancer properties, king trumpet polysaccharides act on the host organism’s immune system, augmenting its ability to fend off the invaders in part by stimulating the response of natural killer cells helping them be better killer. 
Polysaccharides in lion’s mane mushrooms can promote neuronal health.  An extract of lion’s mane, for example, stimulated the production of nerve growth factor which is involved in regulating and maintaining specific neurons.  Mice given lion’s mane mushrooms in their feed (5% w/w) for 7 days had increased nerve growth factor mRNA expression in the hippocampus, a region of the brain instrumental in learning and memory.  These properties have been implicated in lion’s mane’s ability to reduce neurodegenerative-induced cell death.  In a double-blind study of Japanese men and women aged 50-80 and diagnosed with mild cognitive impairment.  The study participants consumed 250 mg of mushroom tablets containing 96% lion’s mane 3 times per day for 16 weeks. Cognitive function scores increased with the timeframe that the participants ingested the mushrooms.
Glucans from Grifola frondosa or maitake mushrooms provide strong antioxidant and immune-supporting properties [27-29], providing evidence for anti-aging capabilities. Antioxidative properties worked by augmenting key enzymes like superoxide dismutase and glutathione peroxidase activity, which in turn, catalyze the destruction of the superoxide radical and reduce lipid hydroperoxides to alcohols and hydrogen peroxide to water, respectively. Additionally, these glucans increased interleukine-2 (IL-2) production, an immunocytokine that has strong immune-enhancing properties providing the most effective cytokine for T cell biology (a type of white blood cell), as well as the ability to boost the activity of natural killer cells, another type of lymphocyte vital to our immune systems. Malondialdehyde (a common marker for oxidative stress) content in the liver was reduced, further demonstrating maitake’s antioxidant properties.  What’s more, α-glucan from maitake offers anti-tumor activity by promoting the production of cells that enhance our immune systems like tumor necrosis factor α, different interleukins, and through macrophage cell activation.  And a human clinical trial showed that maitake mushrooms led to increased antibodies in in response to influenza type A virus H1N1 after study participants took 20 maitake tablets per day.  Maitake mushrooms also help improve metabolism, showing increased fat metabolism [32,33] and other age-related metabolic issues such as glucose/insulin metabolism (e.g., hyperglycemia) .
Reishi mushrooms, for example, called “the mushroom of immortality” , have been studied for their immune-enhancing, anti-inflammatory, antioxidant, anti-tumor, and antimicrobial properties.  Ganoderma lucidum – the species relevant to this formula – is reported to have over 400 bioactive compounds mostly comprised of polysaccharides and triterpenoids. The immune-enhancing properties of reishi polysaccharides work by increasing the amounts of key immune cells such as natural killer, B-lymphocyte, T-lymphocyte white blood cells, dendritic cells, phagocytes that protect our bodies from foreign particles and may also be examples of white blood cells. A more robust immune system, in turn, is vital in cancer treatment, and reishi polysaccharides stimulate cancer resistance through their immune-enhancing capabilities, by inducing apoptosis (cell death) of cancerous cells, and through their anti-cancer preventing activity. [37,38] Reishi triterpenes offer anti-cancer properties as well, through their toxicity to cancer cells, anti-metastatic effects, and induction of apoptosis. [37-39] Reishi polysaccharides and triterpenes have shown antioxidant and antimicrobial properties, with the terpenes presenting higher antioxidative capacities. The mushroom’s polysaccharides have also demonstrated anti-aging properties through their ability to protect fibroblasts (cells that provides structural framework in mammalian tissue and aids wound healing) from harmful ultraviolet B (UVB) radiation.  The UVB treated cells revealed increased signs of aging and reactive oxygen species and decreased cell viability, but when cells were treated with UVB and reishi polysaccharides, the UVB reactive oxygen species were eliminated. Reishi mushrooms also have been used for their sedative, calming properties. In one study, a reishi extract showed similar anti-anxiety properties as the pharmaceutical drug diazepam.  Reishi powder also diminished fatigue, anxiety, and depression, and provided a better quality of life in 48 breast cancer survivors. 
The consumption of shiitake mushrooms has been shown to improve our immune systems. [43-45] Shiitake’s immune-enhancing properties stem from several mechanisms including an increase in key immune cells such as natural killer T cells.  Beta-glucans in shiitake mushrooms are known to interact with receptors on several types of immune cells. The mushrooms offer anti-tumor properties, not because they directly engage the tumor, but because they activate immune responses in the host.  The polysaccharide lentinan, for example, acts as a host defense potentiators which help hosts defend against various types of cancer. Shiitakes are also known to improve gut health and have led to diminished levels of C-reactive protein, a common marker for inflammation.
Like the other mushrooms in Mike’s Mushroom Mix, turkey tail mushrooms provide strong antioxidant properties.  In addition to polysaccharides and triterpenes, turkey tail offers many phenolic species like flavonols and flavonoids like quercetin. And also like other mushrooms within Mike’s Mushroom Mix, turkey tail mushrooms demonstrate genoprotective capabilities.  In addition to its polysaccharides, turkey tail contains polysaccharides that are also bound to proteins in complexes called polysaccharopeptides. Krestin (PSK) and polysaccharide peptide (PSP) are two such molecules that have strong immune-enhancing properties. PSP, for example, has been shown to increase white blood cells  and PSK stimulates natural killer immune cells.  PSK has also shown powerful anticancer properties, with one study measuring an increased survival in colon cancer patients who received PSK as an adjuvant immunochemotherapy.  An adjuvant therapy seeks to keep the cancer from coming back post-treatment, and an immunotherapy targets the immune system. Turkey tail mushrooms also increase gut health since they contain prebiotics. One study found that consuming 3.6 g per day of PSP from turkey tail led to beneficial microbiome changes and reduced the growth of infectious bacteria such as E. coli and Shigella.  Another study measured higher concentrations of beneficial gut bacteria such as Bifidobacterium and Lactobacillus while detrimental bacteria like Clostridium and Staphylococcus were lessened. 
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 Stamets P. Antipox properties of Fomitopsis officinalis (Vill.: Fr.) Bond. et Singer (Agarikon) from the Pacific Northwest of North America. International Journal of Medicinal Mushrooms. 2005;7:495-506.
 Stamets P. Medicinal polypores of the forests of North America: screening for novel antiviral activity. International Journal of Medicinal Mushrooms. 2005;7:362.
 Teplyakova TV, Psurtseva NV, Kosogova TA, Mazurkova NA, Khanin VA, Vlasenko VA. Antiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altai Mountains (Russia). Int J Med Mushrooms. 2012;14(1):37-45.
 Girometta C. Antimicrobial properties of Fomitopsis officinalis in the light of its bioactive metabolites: a review. Mycology. 2018;10(1):32-39.
 Elkhateeb W, Daba G, Elnahas M, & Thomas P. Fomitopsis officinalis mushroom: ancient gold mine of functional components and biological activities for modern medicine. Egyptian Pharmaceutical Journal. 2019;18:285-289.
 Lin IY, Pan MH, Lai CS, et al. CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways. Sci Rep. 2017;7(1):4862.
 Yu YL, Chen IH, Shen KY, et al. A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation. Eur J Immunol. 2009;39(9):2482-2491.
 Lin CC, Pan IH, Li YR, et al. The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines. PLoS One. 2015;10(2):e0116191.
 Perera N, Yang FL, Lu YT, Li LH, Hua KF, Wu SH. Antrodia cinnamomea galactomannan elicits immuno-stimulatory activity through toll-like receptor 4. Int J Biol Sci. 2018;14(10):1378-1388.
 Balandaykin ME, Zmitrovich IV. Review on chaga medicinal mushroom, Inonotus obliquus (higher basidiomycetes): realm of medicinal applications and approaches on estimating its resource potential. Int J Med Mushrooms. 2015;17(2):95-104.
 Chung MJ, Chung CK, Jeong Y, Ham SS. Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. Nutr Res Pract. 2010;4(3):177-182.
 Mizuno T, Zhuang C, Abe K, Okamoto H, Kiho T, et al. Antitumor and hypoglycemic activities of polysaccharides from the sclerotia and mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae). International Journal of Medicinal Mushrooms. 1999;1:301-316.
 Eid JI, Mohanty S, & Das B. Genoprotective effects of Chaga mushroom (Inonotus obliquus) polysaccharides in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes. bioRxiv. 2020.
 Softa M, Percoco G, Lati E, & Bony P. Birch sap (Betula alba) and chaga mushroom (Inonotus obliquus) extracts show antioxidant, anti-inflammatory and DNA protection/repair activity in vitro. Journal of Cosmetics, Dermatological Sciences and Applications. 2019;09:188-205.
 Diao BZ, Jin WR, Yu XJ. Protective effect of polysaccharides from Inonotus obliquus on Streptozotocin-induced diabetic symptoms and their potential mechanisms in rats. Evid Based Complement Alternat Med. 2014;2014:841496.
 Hong KB, Noh DO, Park Y, Suh HJ. Hepatoprotective activity of water extracts from chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes) against tert-butyl hydroperoxide-induced oxidative liver injury in Primary cultured rat hepatocytes. Int J Med Mushrooms. 2015;17(11):1069-1076.
 Kumar R, Negi PS, Singh B, Ilavazhagan G, Bhargava K, Sethy NK. Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. J Ethnopharmacol. 2011;136(1):260-266.
 Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010;16(5):585-590.
 Zhang B, Li Y, Zhang F, Linhardt RJ, Zeng G, Zhang A. Extraction, structure, and bioactivities of the polysaccharides from Pleurotus eryngii: A review. Int J Biol Macromol. 2020;150:1342-1347.
 Ren D, Wang N, Guo J, Yuan L, Yang X. Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells. Carbohydr Polym. 2016;138:123-133.
 Yang Z, Xu J, Fu Q, et al. Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer. Carbohydr Polym. 2013;95(2):615-620.
 Park YS, Lee HS, Won MH, Lee JH, Lee SY, Lee HY. Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells. Cytotechnology. 2002;39(3):155-162.
 Kawagishi H, Shimada A, Shirai R, Okamoto K, Ojima F, Sakamoto H, et al. Erinacines A, B, and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett. 1994;35:1569–72.
 Mori K, Obara Y, Hirota M, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008;31(9):1727-1732.
 Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H. Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem. 2006;17:525–30.
 Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-372.
 Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014;2(2):14.
 Hong L, Weiyub W, Qina W, Shuzhena G, and Lebin W. Antioxidant and immunomodulatory effects of a a-glucan from fruit body of maitake (Grifola frondosa). Food and Agricultural Immunology. 2013;24(4):409-418.
 Yeh JY, Hsieh LH, Wu KT, Tsai CF. Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake). Molecules. 2011;16(4):3197-3211.
 Masuda Y, Nakayama Y, Tanaka A, Naito K, Konishi M. Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor. PLoS One. 2017;12(3):e0173621.
 Nishihira J, Sato M, Tanaka A, Okamatsu M, Azuma T. et al. Maitake mushrooms (Grifola frondosa) enhances antibody production in response to influenza vaccination in healthy adult volunteers concurrent with alleviation of common cold symptoms. Functional Foods in Health and Disease. 2017; 7:462-482.
 Kabir Y, Hoshino T, Komai M, Kimura S. Histopathological changes in spontaneously hypertensive rats after feeding shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushroom diets. J Clin Biochem Nutr 1989;6:187-193.
 Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Altern Ther Health Med 1996;2:62-66.
 Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol Cell Biochem. 2002;237(1-2):129-136.
 Stamets P. (2000). Growing Gourmet and Medicinal Mushrooms. Berkeley, CA: Ten Speed Press.
 Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009;10(8):717-742.
 Cör D, Knez Ž, Knez Hrnčič M. Antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides: A review. Molecules. 2018;23(3):649.
 Paterson R.R.M. Ganoderma—A therapeutic fungal biofactory. Phytochemistry. 2006;68:1985–2001.
 Sohretoglu D, Huang S. Ganoderma lucidum polysaccharides as an anti-cancer agent. Anticancer Agents Med Chem. 2018;18(5):667-674.
 Zeng Q, Zhou F, Lei L, et al. Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging. Mol Med Rep. 2017;15(1):111-116.
 Ali N, Muhammad A, & Akbar S.A. Anxiolytic-like activity of ethanol extract of Ganoderma lucidum (Reishi) in mice. International Journal of Medical Research and Health Sciences. 2016;5:57-60.
 Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
 Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (Shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. J Am Coll Nutr. 2015;34(6):478-487.
 Nisar J, Mustafa I, Anwar H, et al. Shiitake culinary-medicinal mushroom, Lentinus edodes (Agaricomycetes): a species with antioxidant, immunomodulatory, and hepatoprotective activities in hypercholesterolemic rats. Int J Med Mushrooms. 2017;19(11):981-990.
 Wasser S. Shiitake (Lentinus edodes). In Coates P, Blackman MR, Betz J, Cragg GM, Levine M, Moss J, & White JD. Encyclopedia of Dietary Supplements. 2010.
 Janjušević L, Karaman M, Šibul F, et al. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. J Enzyme Inhib Med Chem. 2017;32(1):355-362.
 Knežević A, Živković L, Stajić M, Vukojević J, Milovanović I, Spremo-Potparević B. Antigenotoxic effect of Trametes spp. extracts against DNA damage on human peripheral white blood cells. Scientific World Journal. 2015;2015:146378.
 Sekhon BK, Sze DM, Chan WK, et al. PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment. Food Chem. 2013;138(4):2201-2209.
 Lu H, Yang Y, Gad E, et al. TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy. Clin Cancer Res. 2011;17(21):6742-6753.
 Sakamoto J, Morita S, Oba K, et al. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunol Immunother. 2006;55(4):404-411.
 Pallav K, Dowd SE, Villafuerte J, et al. Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial. Gut Microbes. 2014;5(4):458-467.
 Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov. 2012;6(1):78-87.